Evaluation of serum creatine phosphokinase in diagnosis of tubal ectopic pregnancy compared with intrauterine pregnancy and threatened abortion
نویسندگان
چکیده
BACKGROUND Vaginal sonograghy and serial -hCG are the most common diagnostic methods for ectopic pregnancy but about 50% of cases are initially misdiagnosed. In tubal pregnancy the zygote lies next to the muscular layer, and this invasion causes an increase in creatine phosphokinase (CPK) in blood. OBJECTIVE assessment of CPK and its isoenzyme CPK-MB as a diagnostic marker for tubal pregnancy. MATERIALS AND METHODS In this case-control study, 111 women between 16-40 years in first-trimester pregnancy admitted to emergency ward of Rasht Alzahra hospital with abdominal pain or vaginal bleeding were included and according to sonography and βhCG divided into 3 groups (N=37): tubal pregnancy (1), threatened abortion (2) and normal pregnancy (3). Blood samples were taken for totalCPK and CPK-MB before any invasive procedure. RESULTS Mean total CPK level were 96.27±63.9 u/lit (group 1), 55.37±14.1 u/lit (group 2) and 48.94±19.2 u/lit (group 3) and was significantly higher in tubal pregnancy compared to other groups. Mean CPK-MB levels in 3 groups were 15.62±5.2 u/lit, 17.32±6.9 u/lit, and 15.1±4.7 u/lit, respectively which was not significant. CONCLUSION It seems that determination of total CPK can enhance the diagnostic value of tubal pregnancy.
منابع مشابه
Assessment of The Diagnostic Capability of Serum Creatine Phosphokinase and Its Isoenzyme in Ectopic Pregnancy
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ارزش اندازهگیری کراتین فسفوکیناز در تشخیص بارداری خارج رحمی
Background and Objective: Early detection of ectopic pregnancy is crucial in saving fertility. Some chemical biomarkers that can differentiate normal intra uterine pregnancy from ectopic pregnancy have been detected. This study was performed to determine the sensitivity and specificity of serum creatine phosphokinase(CPK) measurement for diagnosis of ectopic pregnancy. Materials and Methods: Th...
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